In islet cell transplantation, beta cells are removed from a donor's pancreas and transferred into a person with diabetes. Beta cells are one type of cell found in the islets of the pancreas and produce insulin, which regulates blood sugar levels. Once transplanted, the donor islets begin to make and release insulin.
If you have diabetes, you may already have experienced the nerve pain called diabetic neuropathy. If so, diabetic neuropathy treatment is important.
Some symptoms are obvious: pain in your feet. But more subtle signs of neuropathy are just as critical to notice - and to treat.
"We ask whether people are having unusual tingling or numbness," says Dace L. Trence, MD, an endocrinologist and director of the Diabetes Care Center at the University of Washington Medical Center in Seattle. Those symptoms...
What Are the Benefits of Islet Cell Transplantation?
A successful islet cell transplant can significantly improve the quality of life for a person with diabetes.
Once transplanted, the islet cells resume their role of releasing insulin to maintain normal blood sugar levels in response to food, exercise, and other changes in the body.
Successful islet cell transplantation can provide the following benefits:
Restore or improve the body’s ability to regulate blood sugar levels. The need for frequent blood sugar measurements and daily insulin injections can be reduced, and in a minority of patients, eliminated three years after transplantation. Although being free from insulin injections may only last several months or a year, islet cell transplantation reduces episodes of low blood sugar for a longer time.
As with all organ and tissue transplants, rejection of the donor cells is the greatest challenge. The immune system serves to protect the body from "invading" substances that do not belong -- bacteria and viruses, for example. Even though the transplanted islet cells are beneficial, the recipient's immune system recognizes it as "foreign" and tries to destroy it. This attack on the donor tissue is called "rejection."
All transplant recipients must take, for the rest of their life, strong drugs to suppress the immune response and prevent rejection. Many of these drugs have serious side effects. The long-term effects of these immunosuppressive or anti-rejection drugs are not yet known, but it is suspected that they may increase the risk of cancer.
How Successful Is Islet Cell Transplantation for Diabetes?
Scientists developed the procedure for transplanting islet cells to treat diabetes in the 1960s. The first transplantation attempts, which began in the 1990s, succeeded only 8% of the time, which was attributed to the fact that anti-rejection drugs available at the time interfered with insulin's effectiveness.
Get the latest Diabetes newsletter delivered to your inbox!
Your level is currently
If the level is below 70 or you are experiencing symptoms such as shaking, sweating or difficulty thinking, you will need to raise the number immediately. A quick solution is to eat a few pieces of hard candy or 1 tablespoon of sugar or honey. Recheck your numbers again in 15 minutes to see if the number has gone up. If not, repeat the steps above or call your doctor.
People who experience hypoglycemia several times in a week should call their health care provider. It's important to monitor your levels each day so you can make sure your numbers are within the range. If you are pregnant always consult with your health care provider.
Congratulations on taking steps to manage your health.
However, it's important to continue to track your numbers so that you can make lifestyle changes if needed. If you are pregnant always consult with your physician.
Your level is high if this reading was taken before eating. Aim for 70-130 before meals and less than 180 two hours after meals.
Even if your number is high, it's not too late for you to take control of your health and lower your blood sugar.
One of the first steps is to monitor your levels each day. If you are pregnant always consult with your physician.
Thank you for signing up for the WebMD Diabetes Newsletter!
You'll find tips and tricks as well as the latest news and research on Diabetes.
Did You Know Your Lifestyle Choices
Affect Your Blood Sugar?
Use the Blood Glucose Tracker to monitor
how well you manage your blood sugar over time.