Another Study Suggests Inflammation May Trigger Diabetes
WebMD News Archive
Diabetes specialist Zachary Bloomgarden, MD, tells WebMD that the new study is interesting but not convincing. He points out that Ridker is measuring very low levels of the blood factors, so low that the elevations reported don't suggest "clinical inflammation," meaning that there would be none of the usual physical signs of inflammation such as swelling.
So what Ridker is seeing, says Bloomgarden, may be another aspect of these indicators. He says, for example, that CRP is also produced by fat tissue, especially abdominal fat. He says that CRP produced by fat can affect organs "such as the pancreas, leading to a state of insulin resistance." So it may be that the significance of CRP to diabetes is not as an indicator for inflammation but rather as a "mediator," or causative agent, of the disease process.