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Epilepsy Drug Topamax Targets Diabetes

Topamax Appears to Correct Underlying Risk Factors

WebMD Health News

June 16, 2003 (New Orleans) -- For the first time, researchers say they have evidence that a drug can correct underlying risk factors that lead to the development of diabetes.

In a small study, the antiepileptic drug Topamax lowered levels of total cholesterol, blood glucose, and diastolic blood pressure, all components of the "prediabetic syndrome," reports Aaron I. Vinik, MD, PhD, director of the Strelitz Diabetes Research Institutes at Eastern Virginia Medical School in Norfolk. The prediabetic syndrome is the period before full-blown diabetes and also puts a person at a high risk for cardiovascular disease.

Topamax also appears to reverse some of the nerve damage that leads to a painful condition called peripheral neuropathy, one of the most common complications of diabetes, in which diabetic people often feel like their feet are being stabbed by needles or that their hands are on fire, he says.

The bottom line, Vinik tells WebMD, is that "this has given us the first opportunity to change the underlying biology of the disease as opposed to treating its symptoms."

There's still a long way to go, he stresses, noting that he has only studied 11 patients.

"But all the patients in the study improved, so even though the numbers are small, the findings are powerful," he says.

Surprising Findings

In a previous trial, Vinik's team found that Topamax appeared to relieve the symptoms of numbness and pain that characterize peripheral neuropathy. But what was even more striking, he says, is that all the patients in the study unexpectedly lost weight and experienced a drop in cholesterol and diastolic blood pressure levels.

"There was something much more interesting happening to these patients than relief of pain," he says. "It seemed like [Topamax] would possibly address both the inability of the body to process glucose properly and changes in function."

More than 17 million Americans have diabetes, a third of whom are unaware that they have it. An additional 16 million are thought to suffer from prediabetes, meaning they have blood sugar levels that are higher than they should be but are not yet high enough to be considered diabetes.

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