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Diabetes Health Center

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Drug Helps Lower Blood Sugar

Study: Injectable Drug, Called Byetta, May Lower High Blood Sugar in Patients Taking Other Diabetes Drugs
WebMD Health News
Reviewed by Louise Chang, MD

April 2, 2007 -- The injectable diabetes drug Byetta may lower poorly controlled blood sugar in patients with type 2 diabetes, a new study shows.

However, the study was "much too small and much too short," states an editorial published with the study in the Annals of Internal Medicine.

The study included 233 overweight or obese adults with type 2 diabetes in the U.S., Canada, and Spain.

When the study started, the patients were already taking the diabetes drugs Actos or Avandia. Some were also taking the diabetes drug metformin.

However, the patients' blood sugar levels were still too high, according to hemoglobin A1c tests, which show blood sugar control over the previous six to 12 weeks.

Diabetes Drug Study

The researchers included Bernard Zinman, MD, of Mount Sinai Hospital in Toronto. They randomly split the patients into two groups.

Patients in one group were assigned to give themselves two daily injections of Byetta for 16 weeks in addition to the diabetes drugs they were already taking.

For comparison, patients in the other group gave themselves two daily injections of an inactive liquid (placebo) for 16 weeks, in addition to their other diabetes drugs.

None of the patients knew whether they were giving themselves shots of Byetta or the placebo.

At the end of the 16-week study, the patients took hemoglobin A1c tests

Study's Results

During the study, the patients taking Byetta lowered their average hemoglobin A1c level by almost 1 point.

That brought their average hemoglobin A1c level near the upper limit recommended for people with type 2 diabetes.

The Byetta group also lost about 3 pounds during the study, even though the researchers hadn't asked patients in either group to diet, exercise, or make other lifestyle changes.

In comparison, the placebo group didn't improve their average hemoglobin A1c level and didn't change weight in the study.

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