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Victoza for Diabetes: Better Than Byetta?

New Diabetes Drug Victoza Beats Byetta in Study
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WebMD Health News
Reviewed by Louise Chang, MD

June 8, 2009 -- A new diabetes drug -- to be called Victoza if approved -- works better than Byetta, a head-to-head clinical trial shows.

Byetta is the first of the class of type 2 diabetes drugs called GLP-1 analogs. The drug takes advantage of the body's own signaling system to increase insulin output in response to meals. 

Byetta is a popular drug, and it's helped many patients. But liraglutide -- soon to be called Victoza if approved by the FDA -- works better, says Lawrence Blonde, MD, director of the diabetes clinical research unit at Ochsner Clinic Foundation, New Orleans.

"Our direct comparison study shows patients who took liraglutide once a day had a greater reduction in [average blood sugar levels] at the end of the 26-week study than did [Byetta] twice a day," Blonde tells WebMD. "Obviously, once-a-day injections would be preferred by many patients because of the convenience -- and it is not tied to meals. Liraglutide can be taken any time as long as you take it the same time each day."

Blonde and colleagues reported the results of the study -- funded by Victoza maker Novo Nordisk -- at this week's meeting of the American Diabetes Association (ADA) in New Orleans. The study also appears in the June 8 advance online issue of The Lancet.

The study's main focus was how well liraglutide and Byetta lowered A1c, a measure of blood-sugar control over time. The ADA recommends that patients keep their A1c level below 7%. At the start of the study, which enrolled 464 patients with poor blood-sugar control despite standard treatment with metformin and/or a sulfonylurea, study participants' average A1c level was 8.2%.

Byetta helped patients lower their A1c by 0.79%; 43% of patients were able to get their A1c under 7%.

But patients on liraglutide had a 1.12% drop in A1c -- and 54% got their A1c under 7%.

Byetta makes many patients feel nauseous, although this side effect gets better over time. Nausea is also a side effect of liraglutide, but patients got over it much more quickly.

"By week six the proportion of patients with nausea in the liraglutide group was below 10%, whereas it took patients on [Byetta] 22 weeks to reach that value," Blonde says.

Patients on liraglutide had about half as many episodes of too-low blood sugar as those on Byetta. And patients on liraglutide lost a little more weight (7.1 pounds) than patients on Byetta (6.28 pounds), although the difference was not statistically significant.

The findings convince Christophe E.M. DeBlock, MD, and Luc F. Van Gaal, MD, PhD, of the University of Antwerp, Belgium, who reviewed the study for The Lancet.

"Liraglutide provides greater improvements in glycemic control and is better tolerated than [Byetta]," they write. "This novel GLP-1 analog might be a good option for the treatment of type 2 diabetes."

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