Drug Reverses Diabetes-Related Vision Loss
Lucentis Combined With Laser Better Than Laser Alone, Government Study Finds
WebMD News Archive
Few Complications, Better Outcomes
After one year, nearly 50% of the Lucentis-treated patients could read at
least two additional lines on an eye chart or letters that were one-third
smaller than could be recognized before treatment.
Vision loss, defined as loss of two or more lines on an eye chart, was seen
in less than 5% of the patients treated with the biologic drug.
Patients treated with injections of the corticosteroid Trivaris and laser
showed no greater improvement in vision than patients treated with laser
These patients did have greater reduction in retina thickness, but they also
experienced more treatment-related complications than other study
About 30% developed potentially serious eye pressure requiring medication
and 60% developed cataracts.
Few eye-related complications were reported in the Lucentis-treated
patients, and these patients appeared to have no greater risk of heart attack
Genentech: Long-Term Safety Unknown
The study results were published in the April 27 issue of
“These findings provide hope for a new treatment beyond laser for patients
with diabetic macular edema, which may improve their chances of (maintaining)
healthy vision,” says National Eye Institute (NEI) Clinical Director Frederick
Ferris III, MD.
But a spokeswoman for Genentech tells WebMD the company has no plans to seek
approval for Lucentis as a treatment for DME until its own phase III studies of
the drug are complete.
Findings from two such studies are expected in the first half of 2011.
“While the results from this (newly published) study are very encouraging,
we believe it is important to understand the long-term safety and efficacy of
this drug and to study it in patients for longer than one year,” Nikki Levy of
It is also not clear if the company’s older and much cheaper biologic drug
Avastin would be as effective as Lucentis for the treatment of diabetic macular
edema, Ferris said. NEI is conducting a trial comparing Avastin to Lucentis in
patients with age-related macular degeneration.
A dose of Lucentis costs about $2,000, compared to $50 to $200 for a dose of
Avastin. Levy said the annual cost of Lucentis is about $15,500, assuming seven
doses over the course of a year.