Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Diabetes Health Center

Font Size

Blood Test May Predict Risk of Diabetes

Study Shows High Levels of Amino Acids May Be an Early Sign of Type 2 Diabetes Risk
WebMD Health News
Reviewed by Laura J. Martin, MD

March 20, 2011 -- Elevated levels of a group of five amino acids may predict the development of diabetes years before any noticeable symptoms occur, according to a new study.

Researchers found that blood tests that screened for these amino acids accurately predicted risk of type 2 diabetes in otherwise healthy adults as well as in those with traditional risk factors such as obesity.

"These findings could provide insight into metabolic pathways that are altered very early in the process leading to diabetes," says researcher Thomas Wang, MD, of Massachusetts General Hospital's Cardiovascular Research Center, in a news release. "They also raise the possibility that, in selected individuals, these measurements could identify those at highest risk of developing diabetes so that early preventive measures could be instituted."

Researchers say metabolic abnormalities that eventually lead to type 2 diabetes can be present years before diabetes is diagnosed. For example, insulin resistance, where the body does not use insulin effectively, occurs long before blood sugars reach the level seen in type 2 diabetes.

Predicting Diabetes

The study, published in Nature Medicine, followed 2,422 healthy adults with normal blood sugars at the start of the study for 12 years. During this period, 201 developed type 2 diabetes.

Researchers compared blood samples taken at the beginning of the study in 189 participants who developed diabetes and 189 similarly matched participants who did not. Specifically, they screened for levels of 61 various metabolites, small molecules released into the bloodstream by metabolic activities.

The results showed that elevated levels of five amino acids, isoleucine, leucine, valine, tyrosine, and phenylalanine, were associated with the development of type 2 diabetes.

Researchers found that measuring combinations of these five amino acids rather than a single amino acid was a more accurate predictor of future diabetes risk.

In addition, in people closely matched for traditional risk factors for type 2 diabetes, such as obesity or insulin resistance, those with the highest levels of the three most predictive amino acids -- isoleucine, phenylalanine, and tyrosine -- had a five to seven times higher risk of developing type 2 diabetes than those with the lowest levels.

Researchers say several of these amino acids have also been associated with the development of diabetes in previous studies, but further studies in larger numbers of people will be needed to confirm these results.

Today on WebMD

Diabetic tools
Symptoms, diagnosis, treatment, and more.
woman flexing muscles
10 strength training exercises.
Blood sugar test
12 practical tips.
Tom Hanks
Stars living with type 1 or type 2.
kenneth fujioka, md
Can Vinegar Treat Diabetes
Middle aged person
jennie brand miller

Prediabetes How to Prevent Type 2 Diabetes
type 2 diabetes
food fitness planner