Type 2 Diabetes Treatment Victoza Helps Type 1, Too
Type 1 Diabetes/Victoza Study: Weight Loss, Less Insulin, Better Sugar Control
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Why Victoza Might Help Type 1 Diabetes continued...
Would Byetta work as well as Victoza in type 1 diabetes? That hasn't yet been tested, but Dandona says it should have much the same effect.
Neither Victoza nor Byetta is approved for use in type 1 diabetes. Doctors could prescribe these medications for type 1 diabetes (known as "off-label use), but Dandona says this should be tried only by a endocrinologist specializing in diabetes -- and only with careful and frequent patient monitoring.
GLP-1 inhibitors act on the brain to reduce appetite. Because of the weight loss, thin people with type 1 diabetes should not use these drugs. However, some 30% of people with type 1 diabetes are overweight, so the weight loss would be a benefit to such patients.
Victoza has other more serious side effects. The most important are abdominal pain, nausea, and vomiting, although these side effects tend to lessen or go away after a week or two of treatment. Even so, Dandona says these side effects cause about 5% of type 2 diabetes patients to stop taking the drug.
Although the Dandona study was performed without drug company support, Victoza maker Novo Nordisk is paying for a larger clinical trial. Dandona already has asked the National Institutes of Health to support a large-scale study if this larger study yields similar results to the current pilot study.