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Progress Continues Toward Artificial Pancreas

Goal Is Automated Monitoring of Blood Sugar, Delivery of Insulin
By
WebMD Health News
Reviewed by Louise Chang, MD

June 12, 2012 (Philadelphia) -- Efforts to make an artificial pancreas for people with type 1 diabetes have taken another step forward, with two new studies showing progress toward that goal.

Both studies, presented here at the American Diabetes Association's annual meeting, were small, and more work is needed before an artificial pancreas is ready. For more than three decades, researchers have been trying to develop an artificial pancreas.

But as is often the case, progress in science is measured in baby steps, not leaps. So while preliminary, the studies presented offer renewed hope that an artificial pancreas could become a reality within five to 10 years, experts tell WebMD.

Goal: Artificial Pancreas

Though its name may conjure up images of a manmade organ being grown in a sterile "CSI"-type lab, the artificial pancreas is actually an automated system consisting of a continuous glucose monitor, an insulin infusion pump, and a glucose meter for calibrating the monitor.

The goal is to develop an implantable system that mimics a real pancreas. That's the organ that produces insulin, the hormone that regulates blood sugar levels. In type 1 diabetes, the body's immune system attacks insulin-producing cells in the pancreas.

An artificial pancreas would monitor blood sugar levels, sense when the body needs insulin, calculate the dose needed, and deliver it without a person even being aware of what's happening. It's needed because only about two-thirds of people with diabetes keep their blood sugar at recommended levels throughout the day, says Henry Anhalt, MD, chief medical officer at Animas, which is developing one of the systems.

People with type 1 diabetes give themselves insulin injections or use a pump that delivers insulin via a tiny catheter inserted under the skin. Either way, they have to estimate how much insulin they'll need based on their blood sugar, how much they think they will eat, and how much activity they will be doing.

If they miscalculate, they are at risk for dangerously low blood sugar (hypoglycemia) as well as dangerously high blood sugar (hyperglycemia). In the long run, uncontrolled diabetes can lead to complications such as eye damage, kidney failure, and heart disease.

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