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New Drug for Diabetes-Related Vision Loss

Lucentis Approved to Treat Diabetic Macular Edema
By
WebMD Health News
Reviewed by Louise Chang, MD

Aug. 14, 2012 -- The FDA has approved using the drug Lucentis to treat diabetic macular edema, a common, vision-threatening complication of diabetes.

Lucentis is given via a monthly injection from a health care professional.

In diabetic macular edema, fluid leaks into the macula (the middle of the retina), which is responsible for providing crisp, clear vision. The fluid swells the macula and blurs vision.

“Diabetes is a major public health issue in our country, and all patients with diabetes are at risk of developing diabetic macular edema,” Renata Albrecht, MD, of the FDA’s Center for Drug Evaluation and Research, says in a news release.

Albrecht says the approval “represents a major development for the treatment of people whose vision is impaired by DME as a complication of their disease.”

New Use for Lucentis

Lucentis is already approved to treat other eye disorders, including wet age-related macular degeneration and macular edema caused by blockage of the veins that carry blood away from the retina.

The latest approval for Lucentis was based on two clinical trials involving 759 people who were treated with the drug and followed for three years.

The results showed a significant portion of people with diabetic macular edema treated with Lucentis experienced improvement in vision, as measured by an eye chart.

For example, between 34%-45% of those treated with the recommended 0.3 milligram monthly dose of Lucentis gained at least three lines of vision compared with 12%-18% of those who did not receive the drug.

The most common side effects of Lucentis include bleeding in eye tissue, eye pain, floaters, and increased pressure inside the eye.

Lucentis is marketed in the U.S. by Genentech. A Genentech spokesperson estimates the monthly cost of treatment for diabetic macular edema with Lucentis at $1,170.

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