Medical Dictionary
BRCA2 gene
- a tumor suppressor gene identified in 1995 on chromosome 13 at locus 13q12–q13; a large gene consisting of 27 exons distributed over 70 kb, encoding a protein of 3,418 amino acids. Carriers of germline mutations in BRCA2 have an increased risk, similar to that of those with BRCA1 mutations, of developing breast cancer and a moderately increased risk of ovarian cancer. BRCA2 families also exhibit an increased incidence of male breast, pancreatic, prostate, laryngeal, and ocular cancers. See also: BRCA1 gene, carcinoma of the breast
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Stedman’s Medical Dictionary 28th Edition, Copyright© 2006_Lippincott Williams & Wilkins. All rights reserved.



