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April 4, 2000 (Washington) -- People who took Redux and Pondimin, two diet drugs removed from the market because they were suspected of causing serious heart problems, had only a modest increase in heart valve disorders, and they were usually mild, according to the newest study on these medications.

"Basically, anyone who had taken these drugs certainly for less than three months or so should feel pretty reassured," Julius Gardin, MD, the lead author of the study, tells WebMD. "They should consult their physicians if they have any new symptoms, but if they don't, it would suggest they are in pretty good shape." He says if someone took more than the recommended dose or were taking the drugs for more than three months, his or her physician might consider whether or not a diagnostic heart test is necessary.

Gardin is the chief of cardiology at the University of California, Irvine. The study was published in the April 5 issue of the Journal of the American Medical Association.

Pondimin (fenfluramine) -- which was often given with phentermine, so they are known together as fen-phen -- and Redux (dexfenfluramine) were withdrawn from the market in 1997 after Mayo Clinic physicians reported that up to 30% of people who used them had a leakage in the valve that stops blood from flowing back into the heart, called aortic or mitral valve regurgitation. A handful of studies done after that, however, have failed to find such a high incidence, and this new study, which is the first to look at both medications, is no exception.

The study looked at echocardiograms, or heart ultrasounds, of nearly 500 people who had taken Redux and/or the fen-phen combination. These were compared against those of nearly 500 people who had never taken any of the diet medications. The prevalence of the heart valve disorder in the groups that had taken the medications was not significantly different from the group that had not taken either diet drug, the researchers concluded. Among people who had taken the medications, valve disorders were extremely rare. The groups also showed no difference between the number of heart attacks, irregular rhythms, and other problems that would be considered serious.

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