Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Early Tests of Rats on High-Fat Diet Show Less Obesity With Shots of TLQP-21 Protein

Sept. 18, 2006 -- A protein called TLQP-21 may boost metabolism and limit obesity, at least in rats, a new study shows.

The study appears in Proceedings of the National Academy of Sciences.

The researchers included Alessandro Bartolomucci, PhD. He works in Rome at the Institute of Neuroscience of the Consiglio Nazionale delle Ricerche (National Research Council).

Bartolomucci and colleagues spotted the TLQP-21 protein in rats' brains. They isolated TLQP-21 for lab tests on male rats.

First, the rats ate normal chow for four days. Then they went on a high-fat diet laced with lard.

The rats also got a steady stream of a solution with or without TLQP-21 directly into their brains around the clock for two weeks.

The rats that received TLQP-21 gained less weight and burned more calories at rest on the high-fat diet, compared with those that didn't get TLQP-21.

Metabolism increases were measured by taking the rats' rectal temperature. The rats in the TLQP-21 group showed a rise in rectal temperature.

No people were studied. So it's not known yet if TLQP-21 behaves the same way in people, or what its long-term effects are, even in rats.

TLQP-21 might be part of the complex mix of chemicals involved in obesity.

While scientists sort out the details, people who are overweight and who want to lose weight should talk to their doctors for pointers on safe, effective weight lossweight loss.

WebMD Health News

Healthy Recipe Finder

Browse our collection of healthy, delicious recipes, from WebMD and Eating Well magazine.

Top searches: Chicken, Chocolate, Salad, Desserts, Soup

Heart Rate Calculator

Ensure you're exercising hard enough to get a good workout, but not strain your heart.

While you are exercising, you should count between...