Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Contrave Now Faces Full FDA Approval

Dec. 7, 2010 -- After back-to-back rejections of drugs targeting obesity in the last six months, an FDA advisory committee today voted 13-7 in favor of approving a new medication aimed at aiding people in losing weight and maintaining that weight loss.

The drug, made by Orexigen and to be marketed as Contrave if granted final approval by the FDA, will become one of the few drugs available for the treatment of obesity. The FDA’s decision is due by Jan. 31.

“Clinicians and patients need additional options,” said John Buse, MD, of the University of North Carolina School of Medicine, who addressed the Endocrinologic and Metabolic Drugs Advisory Committee on the drugmaker’s behalf. The risk-to-benefits ratio, he said, “falls clearly on the side of benefits.”

In general, the committee agreed with that statement. However, serious concerns about the drug’s impact on cardiovascular health were the subject of much of the day’s discussion. Supporting documents submitted by the manufacturer showed that the blood pressure of some patients taking Contrave in clinical trials went up as their weight went down.

“I am most distressed about this particular adverse effect,” said committee member Jules Hirsch, MD, of Rockefeller University in New York City. “There needs to be very, very careful attention if this drug is approved.”

To that end, the committee voted 11-8 to require Orexigen to study their drug’s impact on heart health following its approval. In July, they rejected an obesity drug application from drugmaker Vivus; two months later, they voted against Arena Pharmaceutical’s proposed obesity medication, lorcaserin. The FDA formally rejected both drugs in October.

Modest Weight Loss From Contrave

Contrave is a combination of two drugs, both of which have been on the market for about 25 years. Bupropion, commonly prescribed to treat depression and also approved to help people quit smoking, curbs the appetite, while naltrexone, approved to treat opioid and alcohol addictions, amplifies this effect.

That effect may not lead to dramatic weight loss, however. Most patients taking Contrave in clinical trials lost about 5% of their starting body weight.

Healthy Recipe Finder

Browse our collection of healthy, delicious recipes, from WebMD and Eating Well magazine.

Top searches: Chicken, Chocolate, Salad, Desserts, Soup

Heart Rate Calculator

Ensure you're exercising hard enough to get a good workout, but not strain your heart.

While you are exercising, you should count between...