Study Shows the Compound Resveratrol May Prevent Harmful Changes, Such as Insulin Insensitivity
Nov. 2, 2011 -- A compound found in trace amounts in grape skins, peanuts, and red wine may defend against harmful changes seen in obesity that often precede diseases like type 2 diabetes, a small new study shows.
These changes include inflammation in the body and insulin insensitivity.
In previous studies, resveratrol has been shown to extend the lives of obese mice. It also has been shown to increase endurance, helping rodents run about twice as far on a treadmill before they collapse from exhaustion.
Researchers wanted to know if humans who took resveratrol would see similar benefits.
The dose of resveratrol used in the study, 150 milligrams, was far lower than an equivalent dose tested in mice, but it was still hefty. To get the equivalent from red wine, researchers say a person would have to drink more than 13 bottles a day.
All the men took both the resveratrol and the placebo, though the pills were disguised and given four weeks apart, so the men didn't know when they were on each regimen.
"We saw a lot of effects on metabolism that all point toward better metabolic health," says study researcher Patrick Schrauwen, PhD, professor in the metabolic aspects of type 2 diabetes at Maastricht University in the Netherlands.
Activity in mitochondria, the energy factories inside cells, increased. Resveratrol also appeared to change how muscles burned fat, and it lowered some indicators of inflammation.
"Those are also things that you see with exercise training or calorie restriction," Schrauwen says.
But unlike exercise or cutting calories, resveratrol didn't help the men lose weight. In fact, it actually slowed metabolism. Schrauwen says a slower metabolism may be a sign that the body is using energy more efficiently.
"I don't think it will be a drug that will help you to lose weight," he says. "But it may help you to become metabolically more healthy."