Skip to content
My WebMD Sign In, Sign Up

Weight Loss & Diet Plans

Font Size

Study: New Weight Loss Drug May Help Dieters

Overweight and Obese Dieters Lost More Weight With Acomplia Than Placebo

Better Results With Higher Dose

All three groups had some improvement in waist size, cholesterol, triglycerides, and metabolic syndrome. Those changes were significant with Acomplia compared with changes produced with the placebo, say the researchers.

"Treatment with [Acomplia] over one year led to sustained, clinically meaningful weight loss, reduction in waist circumference, and associated improvements with several cardiovascular and metabolic risk factors," says the study.

The lower dose of Acomplia did not have significant effects on these risk factors compared with the placebo except for weight and waist size. The higher Acomplia dose outpaced both other groups in all categories.

Acomplia did not affect blood pressure, says the study.

Acomplia was well tolerated, with generally mild and temporary side effects such as nausea, headache, vomiting, and diarrhea, say the researchers.

Mood disorders were more frequent in the high-dose group. There were nine people in the high-dose group (1.5%) who had psychiatric disorders during the study, compared with two on the lower dose (0.3%) and one taking the placebo (0.3%).

All three groups had similar drop-out rates due to this adverse effect, says the study.

About Acomplia

Acomplia is not currently available for use. However, the drug's maker, Sanofi-Aventis, has been making presentations about Acomplia to investment firms, the company's web site shows.

Acomplia blocks receptors in the brain that are involved in appetite control. It may also help reduce smoking by cutting nicotine cravings.

Van Gaal's study was funded by Sanofi-Aventis. Several of the researchers have received travel awards and honoraria from the drug company to attend scientific meetings or present trial results, says the journal.


Today on WebMD

Woman trying clothes / dress
Woman looking at reflection in mirror
Hot cup of coffee
woman shopping fresh produce
butter curl on knife
eating out healthy
Smiling woman, red hair
6-Week Challenges
Want to know more?
Chill Out and Charge Up Challenge – How to help your tribe de-stress and energize.
Spark Change Challenge - Ready for a healthy change? Get some major motivation.
I have read and agreed to WebMD's Privacy Policy.
Enter cell phone number
- -
Entering your cell phone number and pressing submit indicates you agree to receive text messages from WebMD related to this challenge. WebMD is utilizing a 3rd party vendor, CellTrust, to provide the messages. You can opt out at any time.
Standard text rates apply
What Girls Need To Know About Eating Disorders
teen squeezing into jeans
fitfor Teens

Special Sections