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    Familial Adenomatous Polyposis

    Important
    It is possible that the main title of the report Familial Adenomatous Polyposis is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • adenomatous polyposis of the colon (APC)
    • familial multiple polyposis
    • FAP
    • hereditary polyposis coli
    • multiple polyposis of the colon

    Disorder Subdivisions

    • attenuated FAP
    • familial adenomatous polyposis
    • Gardner syndrome
    • Turcot syndrome

    General Discussion

    Familial adenomatous polyposis (FAP) is a rare inherited cancer predisposition syndrome characterized by hundreds to thousands of precancerous colorectal polyps (adenomatous polyps). If left untreated, affected individuals inevitably develop cancer of the colon and/or rectum. FAP is inherited in an autosomal dominant manner and caused by abnormalities (mutations) in the APC gene. Mutations in the APC gene cause a group of polyposis conditions that have overlapping features: familial adenomatous polyposis, Gardner syndrome, Turcot syndrome and attenuated FAP.

    Resources

    Familial GI Cancer Registry
    Mt. Sinai Hospital
    Joseph and Wolf Lebovic Health Complex
    600 University Avenue
    Toronto
    Ontario, M5T 3L9
    Canada
    Tel: 4165964200
    Fax: 4165855024
    Email: tberk@mtsinai.on.ca
    Internet: http://www.mountsinai.on.ca/care/fgicr

    Johns Hopkins Hereditary Colorectal Cancer Registry
    Johns Hopkins Hospital
    1830 East Monument Stree
    Room 431
    Baltimore, MD 21205
    Tel: (410)955-2635
    Fax: (410)614-8337
    Tel: (888)772-6566
    Email: hccregistry@jhmi.edu
    Internet: http://www.hopkins-gi.org

    American Cancer Society, Inc.
    250 Williams NW St
    Ste 6000
    Atlanta, GA 30303
    USA
    Tel: (404)320-3333
    Tel: (800)227-2345
    TDD: (866)228-4327
    Internet: http://www.cancer.org

    National Cancer Institute
    6116 Executive Blvd Suite 300
    Bethesda, MD 20892-8322
    USA
    Tel: (301)435-3848
    Tel: (800)422-6237
    TDD: (800)332-8615
    Email: cancergovstaff@mail.nih.gov
    Internet: http://www.cancer.gov

    M. D. Anderson Cancer Center Hereditary Colorectal Cancer Registry
    Dept of Gastrointestinal Oncology
    1515 Holcombe Boulevard
    P.O. Box 78
    Houston, TX 77030
    Tel: (713)792-3245
    Fax: (713)745-1163
    Tel: (877)632-6789
    Email: hcc-editor@mdacc.tmc.edu
    Internet: http://www.mdanderson.org/about-us/index.html

    OncoLink: The University of Pennsylvania Cancer Center Resource
    3400 Spruce Street
    2 Donner
    Philadelphia, PA 19104-4283
    USA
    Tel: (215)349-8895
    Fax: (215)349-5445
    Email: hampshire@uphs.upenn.edu
    Internet: http://www.oncolink.upenn.edu

    Strang-Cornell Hereditary Colon Cancer Program
    428 East 72nd Street
    New York, NY 10021
    USA
    Tel: (212)794-4900
    Fax: (212)794-4958
    Email: mbertagnolli@partners.org
    Internet: http://www.strang.org

    Rare Cancer Alliance
    1649 North Pacana Way
    Green Valley, AZ 85614
    USA
    Internet: http://www.rare-cancer.org

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    Madisons Foundation
    PO Box 241956
    Los Angeles, CA 90024
    Tel: (310)264-0826
    Fax: (310)264-4766
    Email: getinfo@madisonsfoundation.org
    Internet: http://www.madisonsfoundation.org

    Friends of Cancer Research
    1800 M Street NW
    Suite 1050 South
    Washington, DC 22202
    Tel: (202)944-6700
    Email: info@focr.org
    Internet: http://www.focr.org

    Cancer.Net
    American Society of Clinical Oncology
    2318 Mill Road Suite 800
    Alexandria, VA 22314
    Tel: (571)483-1780
    Fax: (571)366-9537
    Tel: (888)651-3038
    Email: contactus@cancer.net
    Internet: http://www.cancer.net/

    Cancer Support Community
    1050 17th St NW Suite 500
    Washington, DC 20036
    Tel: (202)659-9709
    Fax: (202)974-7999
    Tel: (888)793-9355
    Internet: http://www.cancersupportcommunity.org/

    Desmoid Tumor Research Foundation
    P.O. Box 273
    Suffern, NY 10901
    Tel: (914)262-6595
    Fax: (845)369-8302
    Email: marlene@dtrf.org
    Internet: http://www.dtrf.org

    Lance Armstrong Foundation
    2201 E. Sixth Street
    Austin, TX 78702
    Tel: (512)236-8820
    Fax: (512)236-8482
    Tel: (877)236-8820
    Email: media@livestrong.org
    Internet: http://www.livestrong.org

    CORE
    3 St. Andrews Place
    London, NW1 4LB
    United Kingdom
    Tel: 02074860341
    Fax: 02072242012
    Email: info@corecharity.org.uk
    Internet: http://www.corecharity.org.uk

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 12/8/2011
    Copyright 1986, 1988, 1989, 1991, 1992, 1994, 1995, 1996, 1997, 1998, 1999, 2000, 2001, 2008, 2011 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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