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    Chronic Intestinal Pseudo-obstruction

    Important
    It is possible that the main title of the report Chronic Intestinal Pseudo-obstruction is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

    Synonyms

    • CIIP
    • CIP
    • chronic idiopathic intestinal pseudo-obstruction
    • pseudo-obstruction syndrome

    Disorder Subdivisions

    • None

    General Discussion

    Summary
    Chronic intestinal pseudo-obstruction (CIP) is a rare, potentially disabling gastrointestinal disorder characterized by abnormalities affecting the involuntary, coordinated muscular contractions (a process called peristalsis) of the gastrointestinal (GI) tract. Peristalsis propels food and other material through the digestive system under the control of nerves, pacemaker cells and hormones. CIP usually results from abnormalities affecting the muscles or nerves that are involved in peristalsis. Consequently, peristalsis becomes altered and inefficient. The symptoms of CIP resemble those caused by mechanical obstruction of the small bowel. Mechanical obstruction refers to something (such as a tumor, scar tissue, etc.) physically blocking the passage of food and other material through the GI tract. In individuals with CIP no such physical obstruction is present, hence the term pseudo-obstruction. Common symptoms include nausea, vomiting, abdominal pain, abdominal swelling (distention) and constipation. Ultimately, normal nutritional requirements cannot be met leading to unintended weight loss and malnourishment. CIP can potentially cause severe, even life-threatening complications.

    Introduction
    There is no agreed upon classification system for CIP and proposed classification systems tend to be complex and confusing. There are also many different causes of CIP, which only adds to the confusion. The unifying concept for CIP regardless of cause is an abnormality affecting the passage of food and other material through the digestive system (gastrointestinal motility). Generally, CIP is broken down into two main forms depending on whether the disorder involves the muscles (myopathic CIP) or nerves (neuropathic CIP) of the GI tract that are involved in peristalsis. Some researchers lump enteric dysmotility together with CIP. The prognosis of this separate yet similar condition is different from CIP. This report deals solely with the strict definition of CIP as a disorder that causes an "obstruction-like" picture.

    Resources

    Association of Gastrointestinal Motility Disorders, Inc.
    12 Roberts Drive
    Bedford, MA 01730
    Tel: (781)275-1300
    Fax: (781)275-1304
    Email: gimotility@gmx.com
    Internet: http://www.agmd-gimotility.org

    Digestive Disease National Coalition
    507 Capitol Court, NE
    Suite 200
    Washington, DC 20002
    Tel: (202)544-7497
    Fax: (202)546-7105
    Email: ddnc@hmcw.org
    Internet: http://www.ddnc.org

    NIH/National Institute of Diabetes, Digestive & Kidney Diseases
    Office of Communications & Public Liaison
    Bldg 31, Rm 9A06
    31 Center Drive, MSC 2560
    Bethesda, MD 20892-2560
    Tel: (301)496-3583
    Email: NDDIC@info.niddk.nih.gov
    Internet: http://www2.niddk.nih.gov/

    International Foundation for Functional Gastrointestinal Disorders
    700 W. Virginia St., 201
    Milwaukee, WI 53217
    USA
    Tel: (414)964-1799
    Fax: (414)964-7176
    Tel: (888)964-2001
    Email: iffgd@iffgd.org
    Internet: http://www.iffgd.org

    Bowel Group for Kids Inc.
    PO Box 40
    Oakdale, NSW, 2570
    Austrailia
    Tel: 02 4659 6067
    Fax: 61 2 4659 6381
    Email: enquiries@bgk.org.au
    Internet: http://www.bgk.org.au

    Genetic and Rare Diseases (GARD) Information Center
    PO Box 8126
    Gaithersburg, MD 20898-8126
    Tel: (301)251-4925
    Fax: (301)251-4911
    Tel: (888)205-2311
    TDD: (888)205-3223
    Internet: http://rarediseases.info.nih.gov/GARD/

    CORE
    3 St. Andrews Place
    London, NW1 4LB
    United Kingdom
    Tel: 02074860341
    Fax: 02072242012
    Email: info@corecharity.org.uk
    Internet: http://www.corecharity.org.uk

    Gastroparesis & Dysmotilities Association
    5520 Dalhart Hill N.W.
    Calgary, AB, T3A 1S9
    Canada
    Tel: 4032473215
    Email: jkf@gpda.net
    Internet: http://www.digestivedistress.com

    For a Complete Report:

    This is an abstract of a report from the National Organization for Rare Disorders (NORD). A copy of the complete report can be downloaded free from the NORD website for registered users. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational therapies (if available), and references from medical literature. For a full-text version of this topic, go to www.rarediseases.org and click on Rare Disease Database under "Rare Disease Information".

    The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

    It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report

    This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

    For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

    Last Updated: 1/5/2012
    Copyright 1987, 1988, 1989, 1994, 2003, 2012 National Organization for Rare Disorders, Inc.

    WebMD Medical Reference from the National Organization for Rare Disorders

    Last Updated: May 28, 2015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.

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