Drugs Ease Hard-to-Treat Constipation
Results of Resolor Study Are Positive; Relistor Helps Opioid Constipation
Constipation Help for Pain Sufferers continued...
Nearly half the Relistor-treated patients had a bowel movement within four
hours of the first dose, compared with 15% of the placebo group. Time to bowel
movement was significantly shorter for Relistor patients than placebo
Importantly, none of the patients showed signs of opioid withdrawal or had
changes in their pain scores.
Relistor "may represent an important therapeutic option for patients
with advanced illness who are suffering from opioid-induced constipation,"
conclude Jay Thomas, MD, PhD, of San Diego Hospice and the Institute for
Palliative Medicine, San Diego, and colleagues.
In an editorial accompanying the Thomas report in the May 29 issue of The
New England Journal of Medicine, Harvard researchers Charles Berde, MD,
PhD, and Samuel Nurko, MD, MPH, commend the Thomas team on its work.
However, Berde and Nurko wonder why only half of patients responded. Their
hypothesis is that the constipating effects of opioids stem not only from
opioid action in the gut, but also in the brain, which Relistor cannot
"Future studies in a larger number of patients may help to delineate
predictors of the success or failure of [Relistor] in specific subgroups of
patients, and may guide decisions about increasing or decreasing the dose for
various patients," they suggest.
Relistor was approved by the FDA in April 2008 for the treatment of
opioid-induced constipation in patients with late-stage, advanced illness who
are receiving opioids on a continuous basis to help alleviate their pain.