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    C. diff on the Rise Outside the Hospital

    Risk Factors for C. diff Include Antibiotic Use and Being Over Age 65
    WebMD Health News
    Reviewed by Louise Chang, MD

    Sept. 20, 2011 (Chicago) -- The potentially dangerous diarrhea bug Clostridium difficile(C. diff.) is making the rounds in the community -- outside the hospital setting it once called home.

    Each year, C. diff strikes about 500,000 Americans, mostly in hospitals and nursing homes. But anywhere from 15,000 to 180,000 of those cases are now acquired in the community, says Erik Dubberke, MD, an infectious diseases specialist at Washington University in St. Louis.

    Why the huge range? Estimates are based on one-year snapshots of different communities, with no studies tracking cases over time, Dubberke tells WebMD.

    "We know community-acquired C. diff is on the rise," though no one knows to what degree, he says.

    C. diff disease can range from mild diarrhea to life-threatening intestinal inflammation known as colitis. The bug produces toxins that destroy the mucosal lining of the gut.

    Dubberke was one of several researchers who discussed C. diff at the 51st Interscience Conference on Antimicrobial Agents and Chemotherapy.

    C. diff Risk Factors

    Most cases of hospital-acquired C. diff occur in people taking so-called broad-spectrum antibiotics, including clindamycin, fluoroquinolones, and penicillins that kill many different types of pathogens.

    Spores enter the body through the mouth, which is the entryway for the gastrointestinal tract. The broad-spectrum antibiotics kill "good" bacteria in the gut that keep C. diff. at bay.

    Use of antibiotics is also a risk factor for community-acquired C. diff, but not to the same degree. Studies implicate antibiotics in as many as 90% of hospital cases, but fewer than half of community-acquired cases, Dubberke says.

    Other risk factors include age over 65 and recent discharge from the hospital. "You’re at risk for the first few weeks after you get out. Then, there's a rapid decline for 12 weeks until you’re back to [average] risk," he says.

    In younger people, underlying medical conditions such as lung disease may increase susceptibility to the bug.

    People who have already had a few bouts with C. diff are especially at risk, says the CDC's C. diff expert, Clifford McDonald, MD.

    "If you've had three or four recurrences, your likelihood of another recurrence is over 50%," he tells WebMD.

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