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C. Diff Vaccine Shows Promise

Vaccine to Prevent Infection With Diarrhea Bug Passes Early Hurdle
WebMD Health News
Reviewed by Laura J. Martin, MD

Oct. 21, 2011 -- A new vaccine shows promise for preventing infection with the potentially dangerous diarrhea bug Clostridium difficile, or C. diff.

In two industry-funded studies of nearly 100 healthy people, the vaccine also proved safe. No serious side effects were associated with its use.

The vaccine targets two toxins, A and B, produced by C. diff that attack the lining of the gut and cause diarrhea, cramping, and other symptoms.

Each year, C. diff strikes about 500,000 Americans, mostly in hospitals and nursing homes.

The new vaccine, being developed by Sanofi-aventis, is one of several vaccines in early testing.

Ginamarie Foglia, DO, MPH, clinical director at Sanofi-aventis, presented the findings today at the annual meeting of the Infectious Diseases Society of America in Boston.

Early Days of Research

There's a huge need for a vaccine to prevent the disease, Foglia tells WebMD. Althoughdiarrhea is its hallmark symptom, C. diff infection can lead to colitis, perforated colon, and even death.

"We see the vaccine being targeted at high-risk people -- the elderly and those with chronic conditions that increase their chance of being hospitalized and being on antibiotics," she says.

More than 90% of hospital infections with C. diff occur in people who have received antibiotic treatment.

The fact that the vaccine specifically targets the two toxins that cause disease is important, says Kevin Garey, PharmD, MS, of the University of Houston School of Pharmacy. He was not involved with the work.

"If you can mount an antibody response to the two toxins, you [would] predict that you have an effective vaccine," he tells WebMD.

Still, these are the very early days, Garey says. "You’d expect the vaccine to be safe in healthy volunteers. Now they have to prove it is safe in high-risk people," he says.

Antibodies Rise After C. Diff Shot

The new studies involved 48 people aged 18 to 55 and 48 people aged 65 and older. Thirty-six people in each group received one of three doses of the vaccine. The rest got placebo.

Everyone got a C. diff shot at the beginning of the study and boosters one month and two months later.

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