Injections of botulinum toxin (Botox) may help heal a tear
(fissure) in the
The internal anal sphincter, one of
two muscles that control the anus, is always under tension. If this tension
(also called resting pressure) is too high, spasms and reduced blood flow can
cause an anal fissure or prevent an existing one from healing. Botulinum toxin,
the poison that causes
botulism, temporarily paralyzes the internal anal
sphincter. This reduces the spasm and allows the fissure to heal.
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Botulinum injections may be more helpful than nitroglycerin ointment, but
the studies do not all agree.1, 2 A review of many studies showed that injections of botulinum
toxin were no better at healing anal fissure than nitroglycerin
ointment.3 Fissures may return after treatment with
Botox is discontinued.
Side effects of botulinum injections may
include the inability to control the passage of gas (gas incontinence), pain
from the injections, bleeding, infection at the injection site, and
fecal incontinence. Most people do not have any side
Botulinum toxin injections can
In this article
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
.gov or call 1-800-4-CANCER.
WebMD Medical Reference from Healthwise
May 15, 2012
This information is not intended to replace the advice of a doctor.
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