Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier
WebMD

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine
WebMD

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion
    WebMD

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community
    WebMD

    Community

    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Font Size
A
A
A

Anal Fissures: Nitroglycerin Ointment - Topic Overview

Application of a 0.2% nitroglycerin ointment may help heal a long-term (chronic) tear, or fissure, in the anus. You rub a pea-sized dot of cream on the fissure twice a day. It is a good idea to either wear gloves when applying the nitroglycerin cream or wash your hands right after. The skin on your fingers can absorb the medicine and increase your chance of side effects.

An increase in muscle tension, also called resting pressure, in the internal anal sphincter can lead to fissures. Spasms and reduced blood flow to the anus may occur along with the rise in pressure, causing fissures or keeping existing fissures from healing.

Recommended Related to Digestive Disorders

Crohn's Disease: 54 Tips to Help You Manage

Crohn's disease, an inflammatory bowel disease affecting 500,000 Americans, can overwhelm your daily life. Day-to-day living is especially difficult if you suffer chronic symptoms like frequent diarrhea, gastrointestinal bleeding, anal tears, or bowel obstructions. Fortunately, treatments for Crohn's disease can make a big difference. Effective treatments range from lifestyle changes to medications, or even surgery in severe cases. The right treatments can reduce symptoms, lengthen remissions,...

Read the Crohn's Disease: 54 Tips to Help You Manage article > >

Nitroglycerin is usually the first medicine used to treat a chronic anal fissure. Many studies have shown that it works better than conservative treatment (eating more fiber and taking sitz baths).1

Headaches are the main side effect of nitroglycerin ointment. The risk of headaches and lightheadedness from low blood pressure is especially high if you use too much ointment at one time.

Some people also may experience itching or burning in the anal area. In some cases, people may develop tolerance to nitroglycerin, meaning that after a while the ointment no longer works to reduce muscle tension.

People using nitroglycerin ointment have increased chances of having low blood pressure. So you should not use nitroglycerin ointment within 24 hours of taking sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra).

WebMD Medical Reference from Healthwise

Last Updated: November 14, 2014
This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
1
Next Article:

Anal Fissures: Nitroglycerin Ointment Topics

Today on WebMD

man holding his stomach
Get the facts on common problems.
blueberries in a palm
Best and worst foods.
 
woman shopping
Learn what foods to avoid.
fresh and dried plums
Will it help constipation?
 
diverticuliltis illustration
Slideshow
couple eating at cafe
Article
 
sick child
Slideshow
Woman blowing bubble gum
Slideshow
 

Send yourself a link to download the app.

Loading ...

Please wait...

This feature is temporarily unavailable. Please try again later.

Thanks!

Now check your email account on your mobile phone to download your new app.

Woman with crohns in pain
Slideshow
Woman with stomach pain
Slideshow
 
diet for diverticulitis
Video
what causes diarrhea
Video