Nonalcoholic steatohepatitis (NASH) most commonly affects people who are middle-aged and obese.

Factors that increase your risk for developing NASH include:

• Fatty liver, or the buildup of fat in liver cells (steatosis).
• Obesity.
• Type 2 diabetes.
• High cholesterol and high triglycerides.
• High blood pressure (hypertension).
• A family history of NASH or cirrhosis, especially cirrhosis of unknown cause (cryptogenic cirrhosis).

Certain treatments for other conditions can also increase your risk of NASH. Some examples of how this could happen include:

• Having had surgery that modifies the intestines, the stomach, or both.
• Using a feeding tube or other method of nutrition delivery for a long time.
• Using certain medicines, including amiodarone, glucocorticoids, synthetic estrogens, and tamoxifen.