About 15 to 20 out of 100 people who use high doses of NSAIDs,
such as people who have rheumatoid arthritis or osteoarthritis, develop sores
in the stomach that look like ulcers when examined with
endoscopy.1 But only a
small number actually develop symptoms or complications of
peptic ulcer disease. Serious complications of peptic
ulcer disease caused by NSAID use are higher in people who:1
Have a prior history of abdominal (belly)
problems, such as an ulcer or bleeding.
thinners (anticoagulants) such as warfarin
(Coumadin) or antiplatelet medicines such as clopidogrel (Plavix) especially when used
in addition to NSAIDs or low-dose aspirin.
You can prevent NSAID ulcers and their complications by not taking
NSAIDs or by only taking them occasionally and in small doses. Be safe with medicines. Read and follow all instructions on the label. If you have to use NSAIDs, your doctor may advise you to take an NSAID that is less likely to cause ulcers. Or your doctor may prescribe a medicine that you take each day to help prevent ulcers. Medicines that help prevent ulcers include:
Your doctor may advise you to get tested for H. pylori bacteria before you start long-term NSAID use. Testing and treatment for H. pylori infection has been shown to reduce the risk of ulcers for people starting long-term NSAID use.1 If you take NSAIDs, be sure to discuss with your doctor the potential risks of long-term NSAID use.
In this article
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
.gov or call 1-800-4-CANCER.
WebMD Medical Reference from Healthwise
November 15, 2013
This information is not intended to replace the advice of a doctor.
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