Zollinger-Ellison syndrome is a rare condition in which tumors called
gastrinomas form in the pancreas or part of the upper small intestine
(duodenum). The tumors secrete large amounts of a hormone called gastrin.
Gastrin signals the stomach to produce more acid.
At some point during their lives, 90% to 95% of
people with Zollinger-Ellison syndrome develop
peptic ulcers, usually in the upper small intestine
Ulcers that occur in people with this syndrome are
often hard to cure but usually can be controlled with a high dose of a proton
This syndrome is extremely rare, but it may be considered as a cause
when a person has severe or repeated peptic ulcers.
Since you were recently diagnosed with chronic constipation, ask your doctor these questions at your next visit.
What is chronic constipation?
Is my chronic constipation a sign of a serious disease such as colon cancer?
Can the medications I take be the cause of chronic constipation?
What medical tests can help determine the cause of chronic constipation?
Are psyllium powder mixes or other over-the-counter (OTC) remedies effective for ending constipation?
If I've been taking ...
Zollinger-Ellison syndrome may occur at any age,
but the symptoms are more likely to appear between the ages of 30 and
In up to two-thirds of people with this syndrome, the tumors
are cancerous (malignant) and may spread to the lymph nodes and liver.
The main treatment for Zollinger-Ellison syndrome is taking proton pump inhibitors and removing the
tumors causing the overproduction of acid. If
this surgery is successful, you will no longer need to take medicines.
In this article
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
.gov or call 1-800-4-CANCER.
WebMD Medical Reference from Healthwise
November 14, 2014
This information is not intended to replace the advice of a doctor.
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