About 1 out of 10 people in Europe and North America will have
peptic ulcer at some time.1
Ulcers can occur at any age, but they are rare in children. Children who do
have ulcers are more likely to have duodenal, rather than gastric,
Peptic ulcer disease tends to occur in people who are also infected
with Helicobacter pylori (H. pylori) bacteria or who use nonsteroidal anti-inflammatory drugs
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About 10 out of 100 people who are infected with
H. pylori develop peptic ulcer disease.2
About 25 out of 100 people who use high
doses of NSAIDs, such as people who have rheumatoid arthritis or
osteoarthritis, develop peptic ulcer disease. About 3 out of 100 will have problems caused by ulcers,
such as bleeding and perforation.3
Cryer B, Spechler SJ (2006). Peptic ulcer disease. In
M Feldman et al., eds., Sleisenger and Fordtran's Gastrointestinal and Liver Disease, 8th ed., vol. 1, pp. 1089-1110.
Philadelphia: Saunders Elsevier.
Feldman M, Le MS (2007). Peptic ulcer diseases. In DC
Dale, DD Federman, eds., ACP Medicine, section 4, chap.
2. New York: WebMD.
Lanza FL, et al. (2009). Guidelines for prevention of NSAID-related ulcer complications. American Journal of Gastroenterology, 104(3): 728-738.
Primary Medical Reviewer
Kathleen Romito, MD - Family Medicine
Specialist Medical Reviewer
Jerome B. Simon, MD, FRCPC, FACP - Gastroenterology
January 28, 2010
WebMD Medical Reference from Healthwise
January 28, 2010
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