Skip to content

    Risks of Using Acetaminophen for Pain Relief

    The most serious risk from acetaminophen is liver damage. Ignoring the dose recommended on the label can put you at risk of severe liver damage.

    People who are at greater risk for liver damage from acetaminophen include people with liver disease and men who drink three or more alcoholic drinks a day (or two a day or more drinks for women).

    Talk to your doctor or pharmacist if you also take the blood thinner warfarin ( Coumadin), because it may increase the risk of bleeding.

    It is important to read the package labeling carefully and not exceed the maximum daily dosage. Because many other OTC and prescription products contain acetaminophen as an active ingredient, make sure to look at the list of active ingredients in other medicines you are taking in order to avoid overdosing.

    Because the signs and symptoms of liver damage from acetaminophen may not be immediately noticeable, if you think you may have taken too much, call 911 or poison control (800-222-1222) immediately.

    The Risks of Combination Medicines

    OTC pain relievers are often used with other ingredients in prescription and non-prescription medications, including some for arthritis, menstrual symptoms, allergies, and sleeplessness. To avoid an overdose, it’s important not to take two medicines that contain the same pain reliever.

    Mixing medicines that contain different pain relievers can also cause problems and should not be done without talking to a doctor.

    Safe Pain Relief for Adults

    Because of the risks of overdosing on a pain medication, it’s important to keep track of how much you take and how long you take it.

    Follow these other drug safety tips for using OTC pain relievers:

    • Read and follow the label. It should clearly state whether a medicine contains acetaminophen or NSAIDs, the risks of the active ingredient, the highest dose you can take safely, and how long you can take it.
    • Wait until you need it. Leave acetaminophen and NSAIDs on the shelf until you really need them. Limiting your intake automatically reduces your risk.
    • Set a cut-off date. Before taking an NSAID, set a date to stop, based on the label’s instructions for how long you should take it before seeing a doctor.
    • Don’t mix medicine with alcohol. If you drink alcohol, talk with your doctor before taking NSAIDs or acetaminophen.

    Choosing an OTC Pain Reliever

    What you need to know to make a safe and effective choice.
    View slideshow

    Pain Relief Poll

    What usually has you reaching for an OTC pain reliever?

    View Results