Antidiabetics, Oral/Oxy-Phenylbutazone Interactions
This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Medical warning:
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, your body may not process your diabetes medicine properly.
What might happen:
An increase in the effects of your diabetes medicine may occur and may cause low blood sugar levels.
What you should do about this interaction:
If you experience a sudden onset of cold sweat, dizziness, fatigue, shakiness, rapid heartbeat, nausea, vision changes, confusion, personality change, nervousness, or hunger, contact your doctor. It may be necessary to check your blood sugar levels more often. Your doctor may want to adjust the dose of your diabetes medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
- 1.Field JB, Ohta M, Boyle C, Remer A. Potentiation of acetohexamide hypoglycemia by phenylbutazone. N Engl J Med 1967 Oct 26;277(17):889-94.
- 2.Tannenbaum H, Anderson LG, Soeldner JS. Letter: Phenylbutazone-tolbutamide drug interaction. N Engl J Med 1974 Feb 7;290(6):344.
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CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.