Skip to content
My WebMD Sign In, Sign Up
Epitol

Interactions

Anticoagulants/Carbamazepine

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known. Carbamazepine may interfere with the way your body processes your blood thinner.

What might happen:

The beneficial effects of your blood thinner may decrease. Your chance of forming a blood clot may increase.

What you should do about this interaction:

This interaction is most likely to occur when starting, stopping, or changing the dose of your carbamazepine. Your doctor may want to check your blood tests more often during those times. It may be necessary to adjust the dose of your blood thinner.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. If your doctor prescribes these two medicines together, you may need to check your bleeding times more often. Do not stop, start, or change the dosage of any medicine before checking with them first.

References:

1.Hansen JM, Siersboek-Nielsen K, Skovsted L. Carbamazepine-induced acceleration of diphenylhydantoin and warfarin metabolism in man. Clin Pharmacol Ther 1971 May-Jun;12(3):539-43.

2.Ross JR, Beeley L. Interaction between carbamazepine and warfarin. Br Med J 1980 Jun 14;280(6229):1415-6.

3.Kendall AG, Boivin M. Warfarin-carbamazepine interaction. Ann Intern Med 1981 Feb;94(2):280.

4.Massey EW. Effect of carbamazepine on Coumadin metabolism. Ann Neurol 1983 Jun;13(6):691-2.

5.Denbow CE, Fraser HS. Clinically significant hemorrhage due to warfarin-carbamazepine interaction. South Med J 1990 Aug;83(8):981.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

More about Drugs and Medications

Newsletters

Subscribe to free WebMD newsletters.

  • WebMD Daily

    WebMD Daily

    Subscribe to the WebMD Daily, and you'll get today's top health news and trending topics, and the latest and best information from WebMD.

  • Men's Health

    Men's Health

    Subscribe to the Men's Health newsletter for the latest on disease prevention, fitness, sex, nutrition, and more from WebMD.

  • Women's Health

    Women's Health

    Subscribe to the Women's Health newsletter for the latest on disease prevention, fitness, sex, diet, anti-aging, and more from WebMD.

By clicking Submit, I agree to the WebMD Terms & Conditions & Privacy Policy

URAC: Accredited Health Web Site HONcode Seal AdChoices