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This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Loperamide may decrease how much saquinavir is absorbed by your body.

What might happen:

The amount of saquinavir in your blood may decrease and it may not work as well.

What you should do about this interaction:

Discuss using these medicines together with your healthcare professional (e.g. doctor or pharmacist). Your doctor may want you to use another medicine for diarrhea or check the amount of saquinavir in your blood.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.


1.Mikus G, Schmidt L, Burhenne J, Ding R, Riedel KD, Tayrouz Y, Weiss J, Haefeli WE. Reduction of saquinavir exposure by coadministration of loperamide: a two-way pharmacokinetic interaction. Clin Pharmacokinet 2004;43(14):1015-24.

2.Imodium (loperamide hydrochloride) US prescribing information. Janssen Pharmaceutica, Inc. October, 2005.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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