Skip to content
My WebMD Sign In, Sign Up
Adipost

Interactions

Guanethidine/Sympathomimetics (Indirect Acting)

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your sympathomimetic may decrease the ability of guanethidine to lower your blood pressure.

What might happen:

Your blood pressure may increase.

What you should do about this interaction:

If your doctor prescribes these two medicines together, you may need to check your blood pressure more often. It may be necessary to change you to a different blood pressure medicine.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this drug interaction and may be monitoring you for it. Do not stop, start, or change the dosage of any medicine before checking with them first.

References:

1.Day MD. Effect of sympathomimetic amines on the blocking action of guanethidine, bretylium and xylocholine. Br J Pharmacol 1962;18:421-39.

2.Day MD, Rand MJ. Antagonism of guanethidine by dexamphetamine and other related sympathomimetic amines. J Pharm Pharmacol 1962 Sep;14:541-9.

3.Gokhale SD, Gulati OD, Udwadia BP. Antagonism of the adrenergic neurone blocking action of guanethidine by certain antidepressant and antihistamine drugs. Arch Int Pharmacodyn Ther 1966 Apr;160(2):321-9.

4.Gulati OD, Dave BT, Gokhale SD, Shah KM. Antagonism of adrenergic neuron blockade in hypertensive subjects. Clin Pharmacol Ther 1966 Jul-Aug; 7(4):510-4.

5.Misage JR, McDonald RH Jr. Antagonism of hypotensive action of bethanidine by "common cold" remedy. Br Med J 1970 Nov 7;4(731):347.

6.Starke K. Interactions of guanethidine and indirect-acting sympathomimetic amines. Arch Int Pharmacodyn Ther 1972 Feb;195(2):309-14.

7.Ober KF, Wang RI. Drug interactions with guanethidine. Clin Pharmacol Ther 1973 Mar-Apr;14(2):190-5.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

More about Drugs and Medications

URAC: Accredited Health Web Site HONcode Seal AdChoices