This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Itraconazole or oral ketoconazole may slow down how quickly your body processes busulfan.
What might happen:
The amount of busulfan in your blood may increase and cause more side effects than expected.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Be sure to keep all laboratory appointments. Let your doctor know if you develop any signs of an infection such as fever, chills, persistent sore throat; easy bruising or bleeding; unusual tiredness or fatigue; or abdominal pain.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Buggia I, Zecca M, Alessandrino EP, Locatelli F, Rosti G, Bosi A, Pession A, Rotoli B, Majolino I, Dallorso A, Regazzi MB. Itraconazole can increase systemic exposure to busulfan in patients given bone marrow transplantation. GITMO (Gruppo Italiano Trapianto di Midollo Osseo). Anticancer Res 1996 Jul-Aug;16(4A):2083-8.
2.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
3.Busulfex (busulfan) US prescribing information. Otsuka America Pharmaceutical, Inc. January, 2015.
4.Myleran (busulfan) US prescribing information. GlaxoSmithKline February, 2005.