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ketoconazole

Interactions

Ixabepilone/Strong CYP3A4 Inhibitors

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines may slow down how quickly your liver processes ixabepilone.

What might happen:

The amount of ixabepilone in your blood may increase and cause more side effects than normally expected.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may want to adjust the dose of your ixabepilone during and for one week after you stop taking your other medicine. Your doctor may want to check the amounts of cells in your blood more often while you are taking these medicines together. Be sure to keep all of your laboratory appointments. Let your doctor know right away if you develop numbness/tingling/burning of the hands or feet; if you have any signs of infections such as fever, chills, cough, or burning/pain when you urinate; or signs of heart problems such as chest pain, difficulty breathing, palpitations, or unusual weight gain.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Ixempra (ixabepilone) US prescribing information. Bristol-Myers Squibb Company October, 2011.

2.US Food and Drug Administration (FDA). Drug Development and Drug Interactions: Table of Substrates, Inhibitors and Inducers. Available at: http://www.fda.gov/Drugs/DevelopmentApprovalProcess/DevelopmentResources/D rugInteractionsLabeling/ucm093664.htm. Updated 08/05/2011.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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