How the interaction occurs:
Your medicine may slow down how quickly your liver processes bosentan.
What might happen:
The amount of bosentan in your blood may increase and cause side effects such as severe headache, fluid retention (edema), nausea, vomiting, or liver problems.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Your doctor may need to change the dosage of your medicine. If you are having headaches, nausea, vomiting, fluid retention, fever, unusual tiredness, abdominal pain, or yellowing of the skin or whites of your eyes, contact your doctor.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Tracleer (bosentan) US prescribing information. Actelion Pharmaceuticals US, Inc. October, 2012.
2.Nizoral (ketoconazole oral) US prescribing information. Janssen Pharmaceuticals February, 2014.
3.This information is based on or an extract from the UW Metabolism and Transport Drug Interaction Database (DIDB) Platform, Copyright University of Washington 1999-2014..