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Marplan

Interactions

Serotonin Reuptake Inhibitors; SNRIs/Selected MAOIs

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Both of these medicines can increase the level of serotonin in your body.

What might happen:

High serotonin levels may cause changes in body temperature, blood pressure and behavior, leading to a medical condition called Serotonin Syndrome. Serotonin Syndrome may be life threatening.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.If you experience muscle twitching, tremors, shivering or stiffness, fever, heavy sweating, heart palpitations, restlessness, confusion, agitation, trouble with coordination, or severe diarrhea contact your doctor right away.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

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11.Zoloft (sertraline) US prescribing information. Pfizer Inc. December, 2012.

12.Effexor (venlafaxine hydrochloride) US prescribing information. Wyeth Pharmaceuticals December, 2012.

13.Luvox (fluvoxamine maleate) US prescribing information. ANI Pharmaceuticals November, 2012.

14.Serzone (nefazodone hydrochloride) US prescribing information. Bristol-Myers Squibb Company January, 2005.

15.Paxil (paroxetine hydrochloride) US prescribing information. GlaxoSmithKline December, 2012.

16.Pexeva (paroxetine mesylate) US prescribing information. Noven Therapeutics, LLC December, 2012.

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29.Zelapar (selegiline hydrochloride) US prescribing information. Valeant Pharmaceuticals December, 2008.

30.Savella (milnacipran hydrochloride) US prescribing information. Forest Pharmaceuticals, Inc. October, 2013.

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39.Azilect (rasagiline) US prescribing information. Teva Neurosciences Inc. December, 2009.

40.Eldepryl (selegiline) US prescribing information. Somerset Pharmaceuticals February, 1997.

41.Pristiq (desvenlafaxine succinate) US prescribing information. Wyeth Pharmaceuticals, Inc. December, 2013.

42.Viibryd (vilazodone hydrochloride) US prescribing information. Forest Laboratories Inc. April, 2014.

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45.USFood and Drug Administration. FDA Drug Safety Communication: Serious CNS reactions possible when methylene blue is given to patients taking certain psychiatric medications. available at: http://www.fda.gov/Drugs/DrugSafety/ucm263190.htm July 26, 2011.

46.USFood and Drug Administration. FDA Drug Safety Communication: Updated information about the drug interaction between linezolid (Zyvox) and serotonergic psychiatric medications. available at: http://www.fda.gov/Drugs/DrugSafety/ucm276251.htm October 21, 2011.

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49.Priligy (dapoxetine hydrochloride) Australian prescribing information. Ortho-McNeil Pharmaceutical March 19, 2013.

50.Brintellix (vortioxetine) US prescribing information. Takeda Pharmaceuticals America, Inc. September, 2013.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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