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OxyIR

Interactions

Methadone: Oxycodone/St. John's Wort

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

St. John's wort may speed up how quickly your liver processes methadone and oxycodone.

What might happen:

The amount of methadone or oxycodone in your blood may decrease and it may not work as well or you may have symptoms of withdrawal.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together and if you have any symptoms of withdrawal or if your methadone or oxycodone is not effective for your pain. Let your doctor know if you stop taking St. John's wort. Your doctor may need to change the dose of your medication.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Eich-Hochli D, Oppliger R, Golay KP, Baumann P, Eap CB. Methadone maintenance treatment and St. John's Wort - a case report. Pharmacopsychiatry 2003 Jan;36(1):35-7.

2.Dolophine (methadone hydrochloride) US prescribing information. Roxane Laboratories, Inc. July, 2012.

3.Nieminen TH, Hagelberg NM, Saari TI, Neuvonen M, Laine K, Neuvonen PJ, Olkkola KT. St John's wort greatly reduces the concentrations of oral oxycodone. Eur J Pain 2010 Sep;14(8):854-9.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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