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Crixivan

Interactions

Tadalafil/Protease Inhibitors (mono deleted 06/12/2014)

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Protease inhibitors may slow down how quickly your liver processes tadalafil.

What might happen:

Your blood levels of tadalafil may increase and cause harmful effects.

What you should do about this interaction:

Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Contact your doctor if you experience a painful or prolonged erection, fainting or dizziness, or changes in vision. The dose of your tadalafil may need adjusting.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Cialis (tadalafil) US prescribing information. Eli Lilly and Company February, 2010.

2.Reyataz (atazanavir sulfate) US prescribing information. Bristol-Myers Squibb Company August, 2013.

3.Prezista (darunavir) US prescribing information. Tibotec Inc. November, 2013.

4.Lexiva (fosamprenavir calcium) US prescribing information. GlaxoSmithKline February, 2013.

5.Crixivan (indinavir sulfate) US prescribing information. Merck & Co., Inc. February, 2011.

6.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories January, 2013.

7.Norvir (ritonavir) US prescribing information. Abbott Laboratories November, 2012.

8.Invirase (saquinavir mesylate) US prescribing information. Roche Laboratories, Inc. February, 2012.

9.Aptivus (tipranavir) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. February, 2012.

10.Viracept (nelfinavir mesylate) US prescribing information. Agouron Pharmaceuticals, Inc. May, 2013.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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