This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug, changing your diet or commencing any course of treatment.
Most important. A change in your diet, medicine, or dosage is likely to be necessary. Promptly consult your doctor or pharmacist.
How the interaction occurs:
Stomach acid is needed in order for itraconazole to dissolve properly.
What might happen:
The presence of food may increase stomach acid levels and improve absorption of itraconazole capsules. Food may interfere with absorption of itraconazole solution. Your blood levels of this medicine may decrease if you do not have normal amounts of stomach acid (e.g., achlorhydria).
What you should do about this interaction:
Take itraconazole capsules with food. Take itraconazole solution without food if possible. If you lack stomach acid (a condition which can be caused by certain stomach/ulcer medicines such as omeprazole or ranitidine), your healthcare professional (e.g., doctor or pharmacist) may recommend use of an acidic product to improve absorption of this medicine. Various methods have been used. Contact your healthcare professional for more information.Your healthcare professionals may be aware of this interaction and may be monitoring you for it. Do not start, stop, or change your medicine or diet before checking with them first.
1.Barone JA, Koh JG, Bierman RH, Colaizzi JL, Swanson KA, Gaffar MC, Moskovitz BL, Mechlinski W, Van de Velde V. Food interaction and steady-state pharmacokinetics of itraconazole capsules in healthy male volunteers. Antimicrob Agents Chemother 1993 Apr;37(4):778-84.
2.Sharkey PK, Rinaldi MG, Dunn JF, Hardin TC, Fetchick RJ, Graybill JR. High-dose itraconazole in the treatment of severe mycoses. Antimicrob Agents Chemother 1991 Apr;35(4):707-13.
3.Sporanox (itraconazole) US prescribing information. Janssen Pharmaceutica Products, L.P. June, 2014.