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nevirapine

Interactions

Lopinavir/Efavirenz; Nevirapine

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Efavirenz and nevirapine may increase how quickly your body processes lopinavir.

What might happen:

The levels of lopinavir in your blood may decrease, making it less effective against your HIV infection.

What you should do about this interaction:

Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Your doctor may want to run blood tests to make sure that your lopinavir is still working. Your doctor may want to increase the dosage of your lopinavir. Do not start, stop, or change the dosage of any medicine before checking with your healthcare professionals first.

References:

1.Kaletra (lopinavir/ritonavir tablets) US prescribing information. Abbott Laboratories January, 2013.

2.Kaletra (lopinavir/ritonavir capsules) US prescribing information. Abbott Laboratories January, 2013.

3.Sustiva (efavirenz) US prescribing information. Bristol-Myers Squibb Company August, 2012.

4.Viramune (nevirapine) US prescribing information. Boehringer Ingelheim Pharmaceuticals, Inc. January, 2014.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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