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Interactions

Selected Dopamine Agonists/Selected Antipsychotics

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Some medicines increase the activity of dopamine in the brain. Antipsychotic medicines block the activity of dopamine in the brain.

What might happen:

Each medicine could counteract the beneficial effects of the other, so one or both medicines may not work as well.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Requip (ropinirole hydrochloride) US prescribing information. GlaxoSmithKline October, 2006.

2.Sinemet (carbidopa/levodopa) US prescribing information. Merck & Co., Inc February, 2011.

3.Stalevo (carbidopa; entacapone; levodopa) US Prescribing Information. Orion/Novartis October 11, 2010.

4.Comtan (entacapone) US prescribing information. Orion Corporation June, 2014.

5.Marras C, Gruneir A, Wang X, Fischer H, Gill SS, Herrmann N, Anderson GM, Hyson C, Rochon PA. Antipsychotics and mortality in Parkinsonism. Am J Geriatr Psychiatry 2012 Feb;20(2):149-58.

6.Oertel WH Berardelli A Bloem Br etal. Chapter 15 - Late (complicated) Parkinson's disease in European Handbook of Neurological Management. 2011; Volume 1, 2nd Edition:237 - 267.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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