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fosphenytoin injection

Interactions

Hydantoins/Sulfonamides

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

When these two medicines are taken together, your body may process your seizure medicine more slowly.

What might happen:

Your blood levels of your seizure medicine may rise and cause an increase in the beneficial and toxic effects.

What you should do about this interaction:

If you experience changes in vision, loss of coordination, drowsiness, nausea, vomiting, or confusion, contact your doctor. It may be necessary to measure the blood levels of your seizure medicine. Your doctor may need to adjust the dose.Your healthcare professionals (e.g. doctor or pharmacist) may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Lumholtz B, Siersbaek-Nielsen K, Skovsted L, Kampmann J, Hansen JM. Sulfamethizole-induced inhibition of diphenlhydantoin, tolbutamide, and warfarin metabolism. Clin Pharmacol Ther 1975 Jun;17(6):731-4.

2.Hansen JM, Kampmann JP, Siersbaek-Nielsen K, Lumholtz IB, Arroe M, Abildgaard U, Skovsted L. The effect of different sulfonamides on phenytoin metabolism in man. Acta Med Scand Suppl 1979;624:106-10.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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