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Drugs & Medications

Prostin E2 vaginal

GENERIC NAME(S): DINOPROSTONE

Uses

This medication is used to cause an abortion during weeks 12-20 of pregnancy. It is also used up to week 28 of pregnancy to help vaginally remove any remaining material in the womb from a miscarriage/missed abortion. This medication causes the womb to contract and push out its contents, including the placenta and the fetus/unborn baby, whether living or not. Dinoprostone is a natural substance (prostaglandin) that your body makes in preparation for labor. It softens and widens the opening of the womb and increases contractions.

It is also used to treat a certain type of womb problem (benign hydatiform mole). This medication should not be used for cervical ripening or any other use in a pregnancy that is near the time of delivery.

How to use Prostin E2 vaginal

This drug is used vaginally. Allow the suppository to warm to room temperature and remove the foil before use. The suppository is inserted high in the vagina by a health care professional, and you must remain in a reclined or lying-down position for at least 10 minutes after insertion. More doses may be used every 3-5 hours until the desired effect occurs. Do not use for more than 48 hours.

This medication should only be used in a hospital setting with trained medical care available. You will be monitored for changes in your womb (e.g., water breaking, strong/long-lasting contractions). If the desired result has not occurred in 48 hours, or if the abortion is not complete, other treatment (e.g., surgical removal) may be needed. This medication may be used with a medication given by vein (oxytocin) to help strengthen the contractions. It is very important that all of the products of pregnancy are removed (e.g., fetal/unborn baby tissue, placenta) to prevent serious, rarely fatal problems such as severe infection and bleeding.

Side Effects

Nausea, vomiting, diarrhea, fever, chills, abdominal pain, flushing, and dizziness may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Most women will experience a fever 15-45 minutes after the suppository is inserted. Sponge baths and drinking lots of fluids may help lower the fever. Aspirin will not usually lower the fever. The fever usually goes away within 6 hours after the last dose. Seek immediate medical attention if you have a high fever (e.g., higher than 101 degrees F or 38 degrees C) after the abortion. Fever may be a sign of a serious infection.

Tell your doctor immediately if any of these rare but very serious side effects occur: fainting, strong contractions that are very close together (uterine overstimulation), severe abdominal pain.

Seek immediate medical attention if this rare but very serious side effect occurs: chest pain.

This drug has rarely caused injury to the womb (uterine rupture), which may require emergency surgery. Your doctor will be monitoring you for signs of uterine overstimulation.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before using this medication, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

This medication should not be used if you have certain medical conditions. Before using this medicine, consult your doctor or pharmacist if you have: severe breathing problem (e.g., uncontrolled asthma), current pelvic problem (active pelvic inflammatory disease), current heart disease (e.g., uncontrolled angina, recent heart attack), liver disease, kidney disease.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: anemia, asthma, high or low blood pressure, diabetes, glaucoma, heart disease (e.g., angina, heart attack), infections in the vaginal/pelvic area (e.g., cervicitis, vaginal infection, genital herpes, pelvic inflammatory disease), seizure disorder, uterine surgery including previous cesarean section (c-section) birth, pelvic problems (e.g., womb scarring, fibroids, cervical stenosis).

This medication should not be used if the unborn baby is mature enough to survive outside the womb. Discuss the risks and benefits with your doctor.

It is not known whether this drug passes into breast milk. Consult your doctor before breast-feeding.

Interactions

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with your doctor or pharmacist first.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: other prostaglandins (e.g., misoprostol).

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

This medicine may be harmful if swallowed. If swallowing or overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Use under direct medical supervision.

Missed Dose

Not applicable.

Storage

Store in a freezer at or below -4 degrees F (-20 degrees C) away from light and moisture. Bring to room temperature just before use. Keep wrapped in foil until just before use.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

Information last revised February 2014. Copyright(c) 2014 First Databank, Inc.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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