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ZOSTAVAX (PF) subcutaneous

Interactions

Zoster Vaccine Live/Pneumococcal Vaccine

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Receiving these two vaccinations too closely together may reduce your immune system's response to the zoster vaccine.

What might happen:

If you receive these vaccines at the same time, you zoster vaccine will still work, but it may not work quite as well as it would if you separate vaccine administration by at least 4 weeks.

What you should do about this interaction:

Make sure your healthcare professionals (e.g. doctor or pharmacist) know about any vaccinations you have recently received. Discuss the timing of your vaccines with your healthcare provider.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Zostavax (zoster vaccine live) US prescribing information. Merck & Co., Inc. September, 2013.

2.MacIntyre CR, Egerton T, McCaughey M, Parrino J, Campbell BV, Su SC, Pagnoni MF, Stek JE, Xu J, Annunziato PW, Chan IS, Silber JL. Concomitant administration of zoster and pneumococcal vaccines in adults >/=60 years old. Hum Vaccin 2010 Nov;6(11):894-902.

3.Centers for Disease Control and Prevention (CDC) National Center for Immunization and Respiratory Diseases. Herpes Zoster Vaccination Information for Health Care Professionals. available at: http://www.cdc.gov/vaccines/vpd-vac/shingles/hcp-vaccination.htm October 19, 2012.

4.Centers for Disease Control and Prevention. General Recommendations on Immunization. Recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR January 28, 2011;60(RR No.2):1-64.

5.Tseng HF, Smith N, Sy LS, Jacobsen SJ. Evaluation of the incidence of herpes zoster after concomitant administration of zoster vaccine and polysaccharide pneumococcal vaccine. Vaccine 2011 May 9;29(20):3628-32.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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