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Drugs & Medications

Sprycel

GENERIC NAME(S): DASATINIB

Uses

This medication is used to treat certain types of cancer (chronic myeloid leukemia and acute lymphoblastic leukemia). It works by slowing or stopping the growth of cancer cells.

How to use Sprycel

Read the Patient Information Leaflet provided by your pharmacist before you start using dasatinib and each time you get a refill. If you have any questions, consult your doctor or pharmacist.

Take this medication by mouth with or without food as directed by your doctor, usually once daily. This medication should be swallowed whole. Do not break, cut, or crush the tablets. Avoid taking antacids (e.g., aluminum/magnesium hydroxide, calcium carbonate) within 2 hours before or after this medication because they will decrease its effectiveness.

The dosage is based on your medical condition, lab tests, response to treatment, and other medications you may be taking. Do not increase your dose or take this medication more often than prescribed. Your condition will not improve any faster, and the risk of serious side effects may be increased. Be sure to tell your doctor and pharmacist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).

Avoid eating grapefruit or drinking grapefruit juice while using this medication unless your doctor or pharmacist says you may do so safely. Grapefruit can increase the chance of side effects with this medicine. Ask your doctor or pharmacist for more details.

Since this drug can be absorbed through the skin and lungs, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the tablets.

Side Effects

Upset stomach, nausea, vomiting, diarrhea, headache, tiredness, muscle pain, body aches, and loss of appetite may occur. If these effects persist or worsen, notify your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor immediately if any of these unlikely but serious side effects occur: dry cough, swelling (especially of lower legs/the area around eyes), sudden/unexplained weight gain, increasing trouble breathing (shortness of breath, dyspnea).

Tell your doctor immediately if any of these rare but very serious side effects occur: black/bloody stools, dark urine, stomach/abdominal pain, vomit that looks like coffee grounds, yellowing eyes/skin.

Seek immediate medical attention if any of these rare but very serious side effects occur: severe dizziness, fainting, fast/slow/irregular heartbeat, chest pain, confusion, weakness on one side of the body.

This medication may cause very serious blood disorders (low number of blood cells such as red cells, white cells, and platelets). This effect can cause anemia, decrease your body's ability to fight an infection, or cause your body to bruise or bleed more easily. Tell your doctor immediately if you develop any of the following symptoms: signs of infection (e.g., fever, persistent sore throat), easy bruising/bleeding, unusual tiredness.

A very serious allergic reaction to this drug is rare. However, seek immediate medical attention if you notice any of the following symptoms of a serious allergic reaction: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before taking dasatinib, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients (such as lactose), which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: bleeding problems, heart problems (e.g., irregular heartbeat), liver problems, a certain lung problem (pulmonary arterial hypertension).

Dasatinib may cause a condition that affects the heart rhythm (QT prolongation). QT prolongation can infrequently result in serious (rarely fatal) fast/irregular heartbeat and other symptoms (such as severe dizziness, fainting) that need medical attention right away.

The risk of QT prolongation may be increased if you have certain medical conditions or are taking other drugs that may cause QT prolongation. Before using dasatinib, tell your doctor or pharmacist of all the drugs you take and if you have any of the following conditions: certain heart problems (heart failure, slow heartbeat, QT prolongation in the EKG), family history of certain heart problems (QT prolongation in the EKG, sudden cardiac death).

Low levels of potassium or magnesium in the blood may also increase your risk of QT prolongation. This risk may increase if you use certain drugs (such as diuretics/"water pills") or if you have conditions such as severe sweating, diarrhea, or vomiting. Talk to your doctor about using dasatinib safely.

Do not have immunizations/vaccinations without the consent of your doctor, and avoid contact with people who have recently received oral polio vaccine or flu vaccine inhaled through the nose. Wash your hands well to prevent the spread of infections.

To lower your risk of getting cut, bruised, or injured, use caution with sharp objects like razors and nail cutters, and avoid activities such as contact sports.

Older adults may be more sensitive to the effects of this drug, especially swelling of the lower legs, sudden/unexplained weight gain, shortness of breath, and QT prolongation (see above).

This drug is not recommended for use during pregnancy. It may harm the unborn baby. If you become pregnant or think you may be pregnant, inform your doctor immediately. To avoid pregnancy, both males and females must use reliable form(s) of birth control (e.g., condoms, birth control pills) during treatment with this drug. Talk with your doctor about effective forms of birth control.

It is not known whether this drug passes into breast milk. Because of the possible risk to the infant, breast-feeding while using this drug is not recommended. Consult your doctor before breast-feeding.

Interactions

See also How to Use section.

Your doctor or pharmacist may already be aware of any possible drug interactions and may be monitoring you for them. Do not start, stop, or change the dosage of any medicine before checking with them first.

This drug should not be used with the following product because very serious interactions may occur: St John's wort.

If you are currently using the medication listed above, tell your doctor or pharmacist before starting dasatinib.

Before using this medication, tell your doctor or pharmacist of all prescription and nonprescription/herbal products you may use, especially of: "blood thinners" (e.g., warfarin, aspirin), H2 blockers (e.g., cimetidine, famotidine, ranitidine), proton pump inhibitors (e.g., lansoprazole, omeprazole, pantoprazole), drugs affecting liver enzymes that remove dasatinib from your body (such as azole antifungals including itraconazole/ketoconazole, corticosteroids including dexamethasone, HIV protease inhibitors including ritonavir/saquinavir, macrolide antibiotics including erythromycin, rifamycins including rifampin/rifabutin, certain anti-seizure medicines including carbamazepine/phenytoin, telithromycin).

If your doctor has prescribed low doses of aspirin to prevent heart attack or stroke (usually at dosages of 81-325 milligrams a day), you should continue to take the aspirin. Consult your doctor or pharmacist for more details.

Avoid taking this medication at the same time as antacids. Wait at least 2 hours between taking this medication and an antacid. (See also How to Use section.)

This drug can slow down the removal of other drugs from your body by affecting certain liver enzymes. These affected drugs include cyclosporine, ergotamine, fentanyl, simvastatin, and tacrolimus, among others. Ask your doctor about using these drugs safely.

Many drugs besides dasatinib may affect the heart rhythm (QT prolongation), including amiodarone, dofetilide, pimozide, procainamide, quinidine, sotalol, macrolide antibiotics (such as erythromycin), among others. Therefore, before using dasatinib, report all medications you are currently using to your doctor or pharmacist.

This document does not contain all possible interactions. Therefore, before using this product, tell your doctor or pharmacist of all the products you use. Keep a list of all your medications with you, and share the list with your doctor and pharmacist.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Do not share this medication with others.

Laboratory and/or medical tests (e.g., magnesium/potassium blood levels, complete blood count, liver function tests) should be performed periodically to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

If you miss a dose, take it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. Do not double the dose to catch up.

Storage

Store at room temperature at 77 degrees F (25 degrees C) away from light and moisture. Brief storage between 59-86 degrees F (15-30 degrees C) is permitted. Do not store in the bathroom. Keep all medicines away from children and pets.

Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed. Consult your pharmacist or local waste disposal company for more details about how to safely discard your product.

MEDICAL ALERT: Your condition can cause complications in a medical emergency. For information about enrolling in MedicAlert, call 1-888-633-4298 (US) or 1-800-668-1507 (Canada).

Information last revised June 2013. Copyright(c) 2013 First Databank, Inc.

Images

SPRYCEL 20 MG TABLET
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SPRYCEL 50 MG TABLET
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SPRYCEL 70 MG TABLET
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SPRYCEL 80 MG TABLET
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SPRYCEL 100 MG TABLET
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SPRYCEL 140 MG TABLET
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SPRYCEL 20 MG TABLET
SPRYCEL 20 MG TABLET

Identification

color
white
shape
round
imprint
BMS, 527
This medicine is a white, round, film-coated tablet imprinted with "BMS" and "527".
SPRYCEL 50 MG TABLET
SPRYCEL 50 MG TABLET

Identification

color
white
shape
oval
imprint
BMS, 528
This medicine is a white, oval, film-coated tablet imprinted with "BMS" and "528".
SPRYCEL 70 MG TABLET
SPRYCEL 70 MG TABLET

Identification

color
white
shape
round
imprint
BMS, 524
This medicine is a white, round, film-coated tablet imprinted with "BMS" and "524".
SPRYCEL 80 MG TABLET

Identification

color
white
shape
triangular
imprint
BMS 80, 855
This medicine is a white, triangular, film-coated tablet imprinted with "BMS 80" and "855".
SPRYCEL 100 MG TABLET

Identification

color
white
shape
oval
imprint
BMS 100, 852
This medicine is a white, oval, film-coated tablet imprinted with "BMS 100" and "852".
SPRYCEL 140 MG TABLET

Identification

color
white
shape
round
imprint
BMS 140, 857
This medicine is a white, round, film-coated tablet imprinted with "BMS 140" and "857".

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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