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DexPak 10 day

Interactions

Selected Anticholinesterase/Corticosteroids

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

The cause of the interaction is not known. Corticosteroids may decrease the effects of your anticholinesterases.

What might happen:

The effects of your anticholinesterases may decrease and cause your symptoms of myasthenia gravis to worsen.

What you should do about this interaction:

If you experience an increase in muscle weakness contact your healthcare professional (e.g. doctor or pharmacist).Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Millikan CH, Eaton LE. Clinical evaluation of ACTH and cortisone in myasthenia gravis. Neurology 1951;1:145-52.

2.Grob D, McGehee Harvey A. Effect of adrenocorticotropic hormone (ACTH) and cortisone administration in patients with myasthenia gravis and report of onset of myasthenia gravis during prolonged cortisone administration. Johns Hopkins Med J 1952;91:124-36.

3.Warmolts JR, Engel WK, Whitaker JN. Alternate-dy prednisone in a patient with myasthenia gravis. Lancet 1970 Dec 5;2(7684):1198-9.

4.Namba T. Corticotropin therapy in patients with myasthenia gravis. Electrophysiologic, pharmacologic studies. Arch Neurol 1972 Feb; 26(2):144-50.

5.Brunner NG, Namba T, Grob D. Corticosteroids in management of severe, generalized myasthenia gravis. Effectiveness and comparison with corticotropin therapy. Neurology 1972 Jun;22(6):603-10.

6.Arsura E, Brunner NG, Namba T, Grob D. High-dose intravenous methylprednisolone in myasthenia gravis. Arch Neurol 1985 Dec; 42(12):1149-53.

7.Johns TR. Long-term corticosteroid treatment of myasthenia gravis. Ann N Y Acad Sci 1987;505:568-83.

8.Drachman DB. Present and future treatment of myasthenia gravis. N Engl J Med 1987 Mar 19;316(12):743-5.

9.Cornelio F, Peluchetti D, Mantegazza R, Sghirlanzoni A, Collarile C. The course of myasthenia gravis in patients treated with corticosteroids, azathioprine, and plasmapheresis. Ann N Y Acad Sci 1987;505:517-25.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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