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Drugs & Medications

Vectibix intravenous

GENERIC NAME(S): PANITUMUMAB

WARNINGS:

Panitumumab has caused very serious skin reactions, which can sometimes lead to serious infections. Tell your doctor immediately if you develop any signs of a skin reaction, including acne, mild rash/itching, warmth/redness/swelling of the skin (including around the nails), dry/flaking skin, or skin sores (especially with pus). Get medical help right away if you develop any signs of a serious infection (such as sepsis), including fever, fast heartbeat, mental/mood changes (such as confusion), or change in the amount of urine.

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Uses

This medication is used alone to treat a certain type of cancer of the colon/rectum (cancer that expresses epidermal growth factor receptor-EGFR) that has spread to other parts of the body. It is used in patients who have not responded to other cancer chemotherapy treatment (e.g., fluorouracil, irinotecan, oxaliplatin). It works by slowing or stopping the growth of cancer cells.

Panitumumab should not be used with cancer chemotherapy drugs because of the increased risk for very serious (possibly fatal) side effects.

How to use Vectibix intravenous

This medication is given by injection into a vein by a health care professional. It is usually given every 14 days or as directed by your doctor. Dosage is based on your weight and response to treatment.

Side Effects

See also Warning section.

Diarrhea, nausea, vomiting, tiredness, constipation, abdominal pain, and growth of eyelashes may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

Remember that your doctor has prescribed this medication because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects.

Tell your doctor right away if you have any serious side effects, including: swelling ankles/feet, unusual weakness, irregular heartbeat, severe muscle spasms, mouth sores, eye redness/itching/irritation, watery eyes, menstrual changes.

Prolonged and/or severe diarrhea may lead to a loss of too much body water and minerals (dehydration). Tell your doctor right away if you develop any of the following: extreme thirst, decreased urination, dizziness, fainting.

Rarely, panitumumab has caused very serious lung disease. Tell your doctor immediately if you develop symptoms of lung disease, including: cough, shortness of breath.

Rarely, panitumumab has caused very serious infusion reactions, including an allergic reaction. Get medical help right away if you develop fever, chills, or symptoms of an allergic reaction.

A very serious allergic reaction to this drug is rare. However, get medical help right away if you notice any symptoms of a serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing.

This is not a complete list of possible side effects. If you notice other effects not listed above, contact your doctor or pharmacist.

In the US -

Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345.

Precautions

Before receiving panitumumab, tell your doctor or pharmacist if you are allergic to it; or if you have any other allergies. This product may contain inactive ingredients, which can cause allergic reactions or other problems. Talk to your pharmacist for more details.

Before using this medication, tell your doctor or pharmacist your medical history, especially of: lung disease (e.g., pulmonary fibrosis, interstitial pneumonitis), low magnesium/calcium blood levels.

Sunlight may worsen any skin reactions that may occur while you are receiving this drug. Avoid prolonged sun exposure, tanning booths, and sunlamps. Use a sunscreen and wear protective clothing when outdoors.

This medication is not recommended for use during pregnancy. It may harm an unborn baby. If you become pregnant or think you may be pregnant, or if your partner becomes pregnant, tell your doctor immediately. To avoid pregnancy, both men and women using this drug should use reliable form(s) of birth control (such as birth control pills, condoms) during treatment and for 6 months after the end of treatment. Consult your doctor for details and to discuss effective forms of birth control.

Based on information from related drugs, this medication may pass into breast milk. Therefore, breast-feeding is not recommended while using this medication and for 2 months after the end of treatment. Consult your doctor before breast-feeding.

Interactions

Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist. Do not start, stop, or change the dosage of any medicines without your doctor's approval.

Overdose

If overdose is suspected, contact a poison control center or emergency room immediately. US residents can call their local poison control center at 1-800-222-1222. Canada residents can call a provincial poison control center.

Notes

Certain laboratory tests may be performed before giving panitumumab to check for the EGFR protein in your tumor.

Laboratory and/or medical tests (such as magnesium/calcium levels) should be performed periodically during treatment and for 8 weeks after completion of treatment to monitor your progress or check for side effects. Consult your doctor for more details.

Missed Dose

For the best possible benefit, it is important to receive each scheduled dose of this medication as directed. If you miss a dose, contact your doctor to establish a new dosing schedule.

Storage

Not applicable. This medication is given in a clinic and will not be stored at home.

Information last revised May 2014. Copyright(c) 2014 First Databank, Inc.

Images

VECTIBIX 100 MG/5 ML VIAL
VECTIBIX 100 MG/5 ML VIAL
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VECTIBIX 400 MG/20 ML VIAL
VECTIBIX 400 MG/20 ML VIAL
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VECTIBIX 100 MG/5 ML VIAL
VECTIBIX 100 MG/5 ML VIAL

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color
colorless
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This medicine is a colorless vial.
VECTIBIX 400 MG/20 ML VIAL
VECTIBIX 400 MG/20 ML VIAL

Identification

color
colorless
shape
No data.
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This medicine is a colorless vial.

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Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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