If you are:
FDB Only When Necessary: INSUFFICIENT HUMAN DATA AVAILABLE; NO DEVELOPMENTAL TOXICITY SEEN IN ANIMALS
Precaution: INSUFFICIENT DATA AVAILABLE
An adult over 60:
management or monitoring precaution: Cardiovascular- Limit initial IV doses to no more than 8 mg for age>74 and no more than 16 mg for ages 66-74. Subsequent doses must not exceed 8 mg and given no sooner than 4-8 hours later. Infuse over a minimum of 15 min. The elderly are more prone to QT prolongation due to multiple meds and iatrogenic hypokalemia, hypomagnesemia; correct electrolytes before giving oral or IV ondansetron. Neuro/Psych-The elderly may be more prone to extrapyramidal reactions associated with IV doses.
Giving Zofran (PF) Solution to a child under 12:
Severe Precaution: Limited information age < 30 days. Longer half-life in infants. Monitor closely.
Severe Precaution: Longer half-life in age < 4 months. Monitor closely.