This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.
Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Ticlopidine may slow down how quickly your liver processes tizanidine.
What might happen:
The amount of tizanidine in your blood may increase and cause more side effects than normal, including severe low blood pressure and drowsiness.
What you should do about this interaction:
Let your healthcare professional (e.g. doctor or pharmacist) know right away that you are using these medicines together. Let your doctor know if you have any fainting or dizziness episodes. Your doctor may want to change the dose of your tizanidine. Use caution when performing tasks that require alertness.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Zanaflex (tizanidine hydrochloride) US prescribing information. Acordia Therapeutics, Inc. July, 2006.
2.Phansalkar S, Desai AA, Bell D, Yoshida E, Doole J, Czochanski M, Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. J Am Med Inform Assoc 2012 Sep-Oct; 19(5):735-43.