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Zanaflex

Interactions

Tizanidine/Selected Fluoroquinolones

This information is generalized and not intended as specific medical advice. Consult your healthcare professional before taking or discontinuing any drug or commencing any course of treatment.

Medical warning:

Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.

How the interaction occurs:

Your antibiotic may slow down how quickly your liver processes tizanidine. Also, tizanidine and some antibiotics can cause a certain type of irregular heartbeat.

What might happen:

The amount of tizanidine in your blood may increase and cause more side effects than normal, including severe low blood pressure and drowsiness. Also, taking some antibiotics with tizanidine may increase your risk of an irregular heartbeat, which may be life-threatening.

What you should do about this interaction:

Let your healthcare professional (e.g. doctor or pharmacist) know right away that you are using these medicines together. Let your doctor know if you notice an irregular heartbeat or have any fainting or dizziness. Your doctor may want to change your medicine. Use caution when performing tasks that require alertness.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.

References:

1.Zanaflex (tizanidine hydrochloride) US prescribing information. Acordia Therapeutics, Inc. July, 2006.

2.Tequin (gatifloxacin) US prescribing information. Bristol-Myers Squibb Company January, 2006.

3.Factive (gemifloxacin mesylate) US prescribing information. Oscient Pharmaceuticals August, 2013.

4.Levaquin (levofloxacin) US prescribing information. Ortho-McNeil Pharmaceutical, Inc. August, 2013.

5.Avelox (moxifloxacin hydrochloride) US prescribing information. Bayer Pharmaceuticals Corporation August, 2013.

6.NegGram (nalidixic acid) US prescribing information. Sanofi-Synthelabo, Inc. November, 2012.

7.Zagam (sparfloxacin) US prescribing information. Bertek Pharmaceuticals, Inc. February, 2003.

8.Drew BJ, Ackerman MJ, Funk M, Gibler WB, Kligfield P, Menon V, Philippides GJ, Roden DM, Zareba W. Prevention of torsade de pointes in hospital settings: a scientific statement from the American Heart Association and the American College of Cardiology Foundation. J Am Coll Cardiol 2010 Mar 2;55(9):934-47.

Selected from data included with permission and copyrighted by First Databank, Inc. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, expect as may be authorized by the applicable terms of use.

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

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